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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SNCA All Species: 29.7
Human Site: Y125 Identified Species: 72.59
UniProt: P37840 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P37840 NP_000336.1 140 14460 Y125 V D P D N E A Y E M P S E E G
Chimpanzee Pan troglodytes XP_001136812 134 14329 Y119 M E P E G E S Y E D P P Q E E
Rhesus Macaque Macaca mulatta XP_001095402 249 25993 Y234 V D P D N E A Y E M P S E E G
Dog Lupus familis XP_535656 140 14461 Y125 V D P D N E A Y E M P S E E G
Cat Felis silvestris
Mouse Mus musculus O55042 140 14467 Y125 V D P G S E A Y E M P S E E G
Rat Rattus norvegicus P37377 140 14497 Y125 V D P S S E A Y E M P S E E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_990004 143 15022 Y128 V D P E N E A Y E M P P E E E
Frog Xenopus laevis NP_001080623 141 14718 Y126 V N P N N E T Y E M P P E E E
Zebra Danio Brachydanio rerio NP_957263 127 13322 T112 L M D P E G Q T Y D D N Q Q E
Tiger Blowfish Takifugu rubipres NP_001029020 127 12563 P112 P E N M A E S P D V T D P A E
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.5 46.1 96.4 N.A. 95 95 N.A. N.A. 86.7 84.4 52.1 57.1 N.A. N.A. N.A. N.A.
Protein Similarity: 100 73.5 51.8 97.1 N.A. 97.1 97.1 N.A. N.A. 92.3 89.3 63.5 69.2 N.A. N.A. N.A. N.A.
P-Site Identity: 100 40 100 100 N.A. 86.6 86.6 N.A. N.A. 80 66.6 0 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 73.3 100 100 N.A. 93.3 93.3 N.A. N.A. 86.6 80 26.6 33.3 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 60 0 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 60 10 30 0 0 0 0 10 20 10 10 0 0 0 % D
% Glu: 0 20 0 20 10 90 0 0 80 0 0 0 70 80 50 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 10 10 10 0 0 0 0 0 0 0 0 50 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 10 10 0 10 0 0 0 0 0 70 0 0 0 0 0 % M
% Asn: 0 10 10 10 50 0 0 0 0 0 0 10 0 0 0 % N
% Pro: 10 0 80 10 0 0 0 10 0 0 80 30 10 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 20 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 20 0 20 0 0 0 0 50 0 0 0 % S
% Thr: 0 0 0 0 0 0 10 10 0 0 10 0 0 0 0 % T
% Val: 70 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 80 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _